RNAi therapy for preeclampsia

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Gene Therapy Using RNAi

In the chapter, we hereby provide a brief review about RNA interference (RNAi) and elucidate its therapeutic applications. The enzymatic synthesis of double-stranded RNA in vitro will be discussed. We also describe how to design and select short interfering RNA (siRNA) sequences. In addition, we also introduce a DNA-directed RNAi (ddRNAi) system, which is designed for the generation of small ha...

متن کامل

Developing RNAi therapy For DYT1 dystonia

DYT1 dystonia is an early onset central nervous system-based movement disorder characterized by uncontrolled sustained muscle contractions that can lead to debilitating abnormal postures. Though a genetic mutation in the gene TOR1A is responsible for most DYT1 cases, the low penetrance of the disease implicates additional genetic and environmental modifiers. Current therapeutic options for DYT1...

متن کامل

RNAi-based nanomedicines for targeted personalized therapy.

RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in order for RNAi to serve as an ideal personalized therapeutics and be clinically approved-safe, specific, and potent strategies must be devised for efficient delivery of RNAi payloads to specific cell types, which despite the immense potential, remains a challenge. Through evaluating the recent reported...

متن کامل

Inching towards a targeted therapy for preeclampsia.

Novel drug development for pregnancy-specific conditions remains a challenge. The reasons for this sentiment are many, but lack of a sound understanding of the pathogenesis for various conditions in pregnancy ranks high among them. Preeclampsia, one of the most common medical complications of pregnancy, has thus far eluded comprehensive biological understanding.1 In the absence of a sound under...

متن کامل

ntioxidant Therapy to Prevent Preeclampsia

Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested linkages, is oxidative stress. This hypothesis predicts that the administration...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Lab Animal

سال: 2020

ISSN: 0093-7355,1548-4475

DOI: 10.1038/s41684-020-0566-5